Abstract
Background:
Free radicals are the main cause of numerous diseases. Their overproduction
needs to be controlled in order to combat several ailments. The current study deals with the discovery
of new free radical scavengers.
Methods:
Substituted N-hydrazinecarbothioamide indazoles 1-18 were evaluated for DPPH and
ABTS radical scavenging activities.
Results:
All synthetic compounds possess good radical DPPH and ABTS scavenging
potential in the ranges of IC50 = 2.11 ± 0.17 - 5.3 ± 0.11 μM and IC50 = 2.31 ± 0.06 - 5.5 ± 0.07
μM, respectively, as compared to standard ascorbic acid having IC50 = 2.02 ± 0.11 μM for DPPH
and IC50 = 2.1 ± 0.07 μM for ABTS.
Conclusion:
These compounds could serve as leads for antioxidant activity that have the ability to
control free radical generation and ward off free radical-induced disorders.