Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Praveen Surendran; Elena V Feofanova; Najim Lahrouchi; Ioanna Ntalla; Savita Karthikeyan; James Cook; Lingyan Chen; Borbala Mifsud; Chen Yao; Aldi T Kraja; James H Cartwright; Jacklyn N Hellwege; Ayush Giri; Vinicius Tragante; Gudmar Thorleifsson; Dajiang J Liu; Bram P Prins; Isobel D Stewart; Claudia P Cabrera; James M Eales; Artur Akbarov; Paul L Auer; Lawrence F Bielak; Joshua C Bis; Vickie S Braithwaite; Jennifer A Brody; E Warwick Daw; Helen R Warren; Fotios Drenos; Sune Fallgaard Nielsen; Jessica D Faul; Eric B Fauman; Cristiano Fava; Teresa Ferreira; Christopher N Foley; Nora Franceschini; He Gao; Olga Giannakopoulou; Franco Giulianini; Daniel F Gudbjartsson; Xiuqing Guo; Sarah E Harris; Aki S Havulinna; Anna Helgadottir; Jennifer E Huffman; Shih-Jen Hwang; Stavroula Kanoni; Jukka Kontto; Martin G Larson; Ruifang Li-Gao; Jaana Lindström; Luca A Lotta; Yingchang Lu; Jian'an Luan; Anubha Mahajan; Giovanni Malerba; Nicholas G D Masca; Hao Mei; Cristina Menni; Dennis O Mook-Kanamori; David Mosen-Ansorena; Martina Müller-Nurasyid; Guillaume Paré; Dirk S Paul; Markus Perola; Alaitz Poveda; Rainer Rauramaa; Melissa Richard; Tom G Richardson; Nuno Sepúlveda; Xueling Sim; Albert V Smith; Jennifer A Smith; James R Staley; Alena Stanáková; Patrick Sulem; Sébastien Thériault; Unnur Thorsteinsdottir; Stella Trompet; Tibor V Varga; Digna R Velez Edwards; Giovanni Veronesi; Stefan Weiss; Sara M Willems; Jie Yao; Robin Young; Bing Yu; Weihua Zhang; Jing-Hua Zhao; Wei Zhao; Evangelos Evangelou; Stefanie Aeschbacher; Eralda Asllanaj; Stefan Blankenberg; Lori L Bonnycastle; Jette Bork-Jensen; Ivan Brandslund; Peter S Braund; Stephen Burgess; Kelly Cho; Cramer Christensen; John Connell; Renée de Mutsert; Anna F Dominiczak; Marcus Dörr; Gudny Eiriksdottir; Aliki-Eleni Farmaki; J Michael Gaziano; Niels Grarup; Megan L Grove; Göran Hallmans; Torben Hansen; Christian T Have; Gerardo Heiss; Marit E Jørgensen; Pekka Jousilahti; Eero Kajantie; Mihir Kamat; AnneMari Käräjämäki; Fredrik Karpe; Heikki A Koistinen; Csaba P Kovesdy; Kari Kuulasmaa; Tiina Laatikainen; Lars Lannfelt; I-Te Lee; Wen-Jane Lee; Allan Linneberg; Lisa W Martin; Marie Moitry; Girish Nadkarni; Matt J Neville; Colin N A Palmer; George J Papanicolaou; Oluf Pedersen; James Peters; Neil Poulter; Asif Rasheed; Katrine L Rasmussen; N William Rayner; Reedik Mägi; Frida Renström; Rainer Rettig; Jacques Rossouw; Pamela J Schreiner; Peter S Sever; Emil L Sigurdsson; Tea Skaaby; Yan V Sun; Johan Sundstrom; Gudmundur Thorgeirsson; Tõnu Esko; Elisabetta Trabetti; Philip S Tsao; Tiinamaija Tuomi; Stephen T Turner; Ioanna Tzoulaki; Ilonca Vaartjes; Anne-Claire Vergnaud; Cristen J Willer; Peter W F Wilson; Daniel R Witte; Ekaterina Yonova-Doing; He Zhang; Naheed Aliya; Peter Almgren; Philippe Amouyel; Folkert W Asselbergs; Michael R Barnes; Alexandra I Blakemore; Michael Boehnke; Michiel L Bots; Erwin P Bottinger; Julie E Buring; John C Chambers; Yii-Der Ida Chen; Rajiv Chowdhury; David Conen; Adolfo Correa; George Davey Smith; Rudolf A de Boer; Ian J Deary; George Dedoussis; Panos Deloukas; Emanuele Di Angelantonio; Paul Elliott; Stephan B Felix; Jean Ferrières; Ian Ford; Myriam Fornage; Paul W Franks; Stephen Franks; Philippe Frossard; Giovanni Gambaro; Tom R Gaunt; Leif Groop; Vilmundur Gudnason; Tamara B Harris; Caroline Hayward; Branwen J Hennig; Karl-Heinz Herzig; Erik Ingelsson; Jaakko Tuomilehto; Marjo-Riitta Järvelin; J Wouter Jukema; Sharon L R Kardia; Frank Kee; Jaspal S Kooner; Charles Kooperberg; Lenore J Launer; Lars Lind; Ruth J F Loos; Abdulla Al Shafi Majumder; Markku Laakso; Mark I McCarthy; Olle Melander; Karen L Mohlke; Alison D Murray; Børge Grønne Nordestgaard; Marju Orho-Melander; Chris J Packard; Sandosh Padmanabhan; Walter Palmas; Ozren Polasek; David J Porteous; Andrew M Prentice; Michael A Province; Caroline L Relton; Kenneth Rice; Paul M Ridker; Olov Rolandsson; Frits R Rosendaal; Jerome I Rotter; Igor Rudan; Veikko Salomaa; Nilesh J Samani; Naveed Sattar; Wayne H-H Sheu; Blair H Smith; Nicole Soranzo; Timothy D Spector; John M Starr; Sylvain Sebert; Kent D Taylor; Timo A Lakka; Nicholas J Timpson; Martin D Tobin; Pim van der Harst; Peter van der Meer; Vasan S Ramachandran; Niek Verweij; Jarmo Virtamo; Uwe Völker; David R Weir; Eleftheria Zeggini; Fadi J Charchar; Nicholas J Wareham; Claudia Langenberg; Maciej Tomaszewski; Adam S Butterworth; Mark J Caulfield; John Danesh; Todd L Edwards; Hilma Holm; Adriana M Hung; Cecilia M Lindgren; Chunyu Liu; Alisa K Manning; Andrew P Morris; Alanna C Morrison; Christopher J O'Donnell; Bruce M Psaty; Danish Saleheen; Kari Stefansson; Eric Boerwinkle; Daniel I Chasman; Daniel Levy; Christopher Newton-Cheh; Patricia B Munroe; Joanna M M Howson; EPIC-InterAct

doi:10.1038/s41588-020-00713-x

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Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Journal article

Peer reviewed

Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Praveen Surendran, Elena V Feofanova, Najim Lahrouchi, Ioanna Ntalla, Savita Karthikeyan, James Cook, Lingyan Chen, Borbala Mifsud, Chen Yao, Aldi T Kraja, …

Nature genetics, Vol.52(12), pp.1314-1332

01/12/2020

DOI: https://doi.org/10.1038/s41588-020-00713-x

PMID: 33230300

Abstract

Blood Pressure - genetics

GATA5 Transcription Factor - genetics

Gene Frequency - genetics

Genetic Predisposition to Disease - genetics

Genome-Wide Association Study

Genotype

Humans

Hypertension - genetics

Mutation - genetics

Phospholipase C beta - genetics

Polymorphism, Single Nucleotide - genetics

Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency ≤ 0.01) variant BP associations (P < 5 × 10 ), of which 32 were in new BP-associated loci and 55 were independent BP-associated single-nucleotide variants within known BP-associated regions. Average effects of rare variants (44% coding) were ~8 times larger than common variant effects and indicate potential candidate causal genes at new and known loci (for example, GATA5 and PLCB3). BP-associated variants (including rare and common) were enriched in regions of active chromatin in fetal tissues, potentially linking fetal development with BP regulation in later life. Multivariable Mendelian randomization suggested possible inverse effects of elevated systolic and diastolic BP on large artery stroke. Our study demonstrates the utility of rare-variant analyses for identifying candidate genes and the results highlight potential therapeutic targets.

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Title: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Creators - without role: Praveen Surendran - University of Cambridge
Elena V Feofanova - The University of Texas Health Science Center at Houston
Najim Lahrouchi - Broad Institute
Ioanna Ntalla - Queen Mary University of London
Savita Karthikeyan - British Heart Foundation
James Cook - University of Liverpool
Lingyan Chen - British Heart Foundation
Borbala Mifsud - William Harvey Research Institute
Chen Yao - National Heart Lung and Blood Institute
Aldi T Kraja - Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA
James H Cartwright - Queen Mary University of London
Jacklyn N Hellwege - VA Tennessee Valley Healthcare System
Ayush Giri - Vanderbilt University Medical Center
Vinicius Tragante - University Medical Center Utrecht
Gudmar Thorleifsson - deCODE Genetics
Dajiang J Liu - Pennsylvania State University
Bram P Prins - British Heart Foundation
Isobel D Stewart - MRC Epidemiology Unit
Claudia P Cabrera - William Harvey Research Institute
James M Eales - University of Manchester
Artur Akbarov - University of Manchester
Paul L Auer - University of Wisconsin–Milwaukee
Lawrence F Bielak - University of Michigan–Ann Arbor
Joshua C Bis - University of Washington
Vickie S Braithwaite - MRC Epidemiology Unit
Jennifer A Brody - University of Washington
E Warwick Daw - Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA
Helen R Warren - William Harvey Research Institute
Fotios Drenos - University College London
Sune Fallgaard Nielsen - Gentofte Hospital
Jessica D Faul - University of Michigan–Ann Arbor
Eric B Fauman - Pfizer
Cristiano Fava - University of Verona
Teresa Ferreira - University of Oxford
Christopher N Foley - British Heart Foundation
Nora Franceschini - University of North Carolina at Chapel Hill
He Gao - Imperial College London
Olga Giannakopoulou - Queen Mary University of London
Franco Giulianini - Brigham and Women's Hospital
Daniel F Gudbjartsson - deCODE Genetics
Xiuqing Guo - UCLA Medical Center
Sarah E Harris - University of Edinburgh
Aki S Havulinna - University of Edinburgh
Anna Helgadottir - deCODE Genetics
Jennifer E Huffman - Western General Hospital
Shih-Jen Hwang - National Institutes of Health
Stavroula Kanoni - Queen Mary University of London
Jukka Kontto - Finnish Institute for Health and Welfare
Martin G Larson - Framingham Heart Study
Ruifang Li-Gao - Leiden University Medical Center
Jaana Lindström - Finnish Institute for Health and Welfare
Luca A Lotta - MRC Epidemiology Unit
Yingchang Lu - Icahn School of Medicine at Mount Sinai
Jian'an Luan - University of Cambridge
Anubha Mahajan - University of Oxford
Giovanni Malerba - University of Verona
Nicholas G D Masca - University of Leicester
Hao Mei - University of Mississippi Medical Center
Cristina Menni - King's College London
Dennis O Mook-Kanamori - Leiden University Medical Center
David Mosen-Ansorena - Imperial College London
Martina Müller-Nurasyid - Helmholtz Zentrum München
Guillaume Paré - McMaster University
Dirk S Paul - British Heart Foundation
Markus Perola - University of Helsinki
Alaitz Poveda - Skåne University Hospital
Rainer Rauramaa - University of Eastern Finland
Melissa Richard - The University of Texas Health Science Center at Houston
Tom G Richardson - University of Bristol
Nuno Sepúlveda - London School of Hygiene & Tropical Medicine
Xueling Sim - National University of Singapore
Albert V Smith - University of Iceland
Jennifer A Smith - University of Michigan–Ann Arbor
James R Staley - British Heart Foundation
Alena Stanáková - University of Eastern Finland
Patrick Sulem - deCODE Genetics
Sébastien Thériault - Population Health Research Institute
Unnur Thorsteinsdottir - deCODE Genetics
Stella Trompet - Leiden University Medical Center
Tibor V Varga - Lund University
Digna R Velez Edwards - Vanderbilt University Medical Center
Giovanni Veronesi - University of Insubria
Stefan Weiss - University of Greifswald
Sara M Willems - MRC Epidemiology Unit
Jie Yao - UCLA Medical Center
Robin Young - University of Cambridge
Bing Yu - The University of Texas Health Science Center at Houston
Weihua Zhang - Imperial College London
Jing-Hua Zhao - British Heart Foundation
Wei Zhao - University of Michigan–Ann Arbor
Wei Zhao - University of Michigan–Ann Arbor
Evangelos Evangelou - Imperial College London
Stefanie Aeschbacher - University Hospital of Basel
Eralda Asllanaj - Greifswald University Hospital
Stefan Blankenberg - German Centre for Cardiovascular Research
Lori L Bonnycastle - National Human Genome Research Institute
Jette Bork-Jensen - Novo Nordisk Foundation
Ivan Brandslund - University of Southern Denmark
Peter S Braund - University of Leicester
Stephen Burgess - British Heart Foundation
Kelly Cho - Harvard Medical School
Cramer Christensen - Lillebaelt Hospital
John Connell - University of Dundee
Renée de Mutsert - Leiden University Medical Center
Anna F Dominiczak - University of Glasgow
Marcus Dörr - Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
Gudny Eiriksdottir - Icelandic Heart Association
Aliki-Eleni Farmaki - UCL Australia
J Michael Gaziano - Harvard Medical School
Niels Grarup - University of Copenhagen
Megan L Grove - The University of Texas Health Science Center at Houston
Göran Hallmans - Umeå University
Torben Hansen - University of Copenhagen
Christian T Have - University of Copenhagen
Gerardo Heiss - Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
Marit E Jørgensen - Steno Diabetes Center
Pekka Jousilahti - Finnish Institute for Health and Welfare
Eero Kajantie - University of Helsinki
Mihir Kamat - National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK
AnneMari Käräjämäki - Diabetes Center, Vaasa Health Care Center, Vaasa, Finland
Fredrik Karpe - University of Oxford
Heikki A Koistinen - Minerva Foundation Institute for Medical Research, Helsinki, Finland
Csaba P Kovesdy - Memphis VA Medical Center
Kari Kuulasmaa - Finnish Institute for Health and Welfare
Tiina Laatikainen - University of Eastern Finland
Lars Lannfelt - Uppsala University
I-Te Lee - Tunghai University
Wen-Jane Lee - Tunghai University
Allan Linneberg - University of Copenhagen
Lisa W Martin - George Washington University
Marie Moitry - University of Strasbourg
Girish Nadkarni - Icahn School of Medicine at Mount Sinai
Matt J Neville - University of Oxford
Colin N A Palmer - University of Dundee
George J Papanicolaou - Epidemiology Branch, NHLBI, Bethesda, MD, USA
Oluf Pedersen - University of Copenhagen
James Peters - Imperial College London
Neil Poulter - Imperial College London
Asif Rasheed - Centre for Non-Communicable Diseases, Karachi, Pakistan
Katrine L Rasmussen - Copenhagen University Hospital
N William Rayner - University of Oxford
Reedik Mägi - University of Tartu
Frida Renström - Umeå University
Rainer Rettig - Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany
Jacques Rossouw - Division of Cardiovascular Sciences, NHLBI, Bethesda, MD, USA
Pamela J Schreiner - University of Minnesota
Peter S Sever - Imperial College London
Emil L Sigurdsson - Primary Health Care
Tea Skaaby - Frederiksberg Hospital
Yan V Sun - Emory University School of Medicine
Johan Sundstrom - Uppsala University
Gudmundur Thorgeirsson - National University Hospital of Iceland
Tõnu Esko - Broad Institute
Elisabetta Trabetti - University of Verona
Philip S Tsao - Stanford University School of Medicine
Tiinamaija Tuomi - Lund University
Stephen T Turner - Mayo Clinic
Ioanna Tzoulaki - University of Ioannina
Ilonca Vaartjes - University Medical Center Utrecht
Anne-Claire Vergnaud - Imperial College London
Cristen J Willer - University of Michigan–Ann Arbor
Peter W F Wilson - Atlanta VA Medical Center
Daniel R Witte - Steno Diabetes Center
Ekaterina Yonova-Doing - University of Cambridge
He Zhang - University of Michigan–Ann Arbor
Naheed Aliya - International Centre for Diarrhoeal Disease Research
Peter Almgren - Lund University
Philippe Amouyel - Institut Pasteur
Folkert W Asselbergs - UCL Australia
Michael R Barnes - Queen Mary University of London
Alexandra I Blakemore - Imperial College London
Michael Boehnke - University of Michigan–Ann Arbor
Michiel L Bots - University Medical Center Utrecht
Erwin P Bottinger - Icahn School of Medicine at Mount Sinai
Julie E Buring - Harvard Medical School
John C Chambers - Imperial College Healthcare NHS Trust
Yii-Der Ida Chen - Framingham Heart Study
Rajiv Chowdhury - Centre for Non-communicable Disease Research (CNCR), Dhaka, Bangladesh
David Conen - Cardiovascular Institute Hospital
Adolfo Correa - University of Mississippi Medical Center
George Davey Smith - University of Bristol
Rudolf A de Boer - University Medical Center Groningen
Ian J Deary - University of Edinburgh
George Dedoussis - Harokopio University of Athens
Panos Deloukas - King Abdulaziz University
Emanuele Di Angelantonio - University of Cambridge
Paul Elliott - Imperial College London
Stephan B Felix - Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany
Jean Ferrières - Department of Cardiology and Department of Epidemiology, INSERM UMR 1027, Toulouse University Hospital, Toulouse, France
Ian Ford - University of Glasgow
Myriam Fornage - The University of Texas Health Science Center at Houston
Paul W Franks - University of Oxford
Stephen Franks - Imperial College London
Philippe Frossard - Centre for Non-Communicable Diseases, Karachi, Pakistan
Giovanni Gambaro - University of Verona
Tom R Gaunt - University of Bristol
Leif Groop - University of Helsinki
Vilmundur Gudnason - University of Iceland
Tamara B Harris - Institute of Aging
Caroline Hayward - University of Edinburgh
Branwen J Hennig - Wellcome Trust
Karl-Heinz Herzig - Poznan University of Medical Sciences
Erik Ingelsson - Stanford University
Jaakko Tuomilehto - National Institute of Public Health, Madrid, Spain
Marjo-Riitta Järvelin - University of Oulu
J Wouter Jukema - Netherlands Heart Institute
Sharon L R Kardia - University of Michigan–Ann Arbor
Frank Kee - Queens University
Jaspal S Kooner - Imperial College Healthcare NHS Trust
Charles Kooperberg - Hutchinson
Lenore J Launer - Institute of Aging
Lars Lind - Uppsala University
Ruth J F Loos - Icahn School of Medicine at Mount Sinai
Abdulla Al Shafi Majumder - National Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka, Bangladesh
Markku Laakso - University of Eastern Finland
Mark I McCarthy - Genentech
Olle Melander - Lund University
Karen L Mohlke - Department of Genetics, University of North Carolina, Chapel Hill, NC, USA
Alison D Murray - University of Aberdeen
Børge Grønne Nordestgaard - Copenhagen University Hospital
Marju Orho-Melander - Lund University
Chris J Packard - University of Glasgow
Sandosh Padmanabhan - University of Glasgow
Walter Palmas - Columbia University Irving Medical Center
Ozren Polasek - University of Split
David J Porteous - University of Edinburgh
Andrew M Prentice - Massachusetts Rehabilitation Commission
Michael A Province - Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA
Caroline L Relton - University of Bristol
Kenneth Rice - University of Washington
Paul M Ridker - Harvard Medical School
Olov Rolandsson - Umeå University
Frits R Rosendaal - Leiden University Medical Center
Jerome I Rotter - Harbor–UCLA Medical Center
Igor Rudan - University of Edinburgh
Veikko Salomaa - Finnish Institute for Health and Welfare
Nilesh J Samani - National Institute for Health Research Leicester Biomedical Research Centre, Leicester, UK
Naveed Sattar - University of Glasgow
Wayne H-H Sheu - National Taipei University
Blair H Smith - University of Dundee
Nicole Soranzo - University of Cambridge
Timothy D Spector - King's College London
John M Starr - University of Edinburgh
Sylvain Sebert - University of Oulu
Kent D Taylor - Harbor–UCLA Medical Center
Timo A Lakka - University of Eastern Finland
Nicholas J Timpson - University of Bristol
Martin D Tobin - University of Leicester
Pim van der Harst - Netherlands Heart Institute
Peter van der Meer - University Medical Center Groningen
Vasan S Ramachandran - Boston University
Niek Verweij - University Medical Center Groningen
Jarmo Virtamo - Finnish Institute for Health and Welfare
Uwe Völker - DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany
David R Weir - University of Michigan–Ann Arbor
Eleftheria Zeggini - Technical University of Munich
Fadi J Charchar - University of Melbourne
Nicholas J Wareham - University of Cambridge
Claudia Langenberg - University of Cambridge
Maciej Tomaszewski - Manchester University NHS Foundation Trust
Adam S Butterworth - University of Cambridge
Mark J Caulfield - Queen Mary University of London
John Danesh - Wellcome Sanger Institute
Todd L Edwards - Vanderbilt University Medical Center
Hilma Holm - deCODE genetics/Amgen, Inc, Reykjavik, Iceland
Adriana M Hung - Vanderbilt University Medical Center
Cecilia M Lindgren - University of Oxford
Chunyu Liu - Boston University
Alisa K Manning - Massachusetts General Hospital
Andrew P Morris - University of Manchester
Alanna C Morrison - The University of Texas Health Science Center at Houston
Christopher J O'Donnell - Brigham and Women's Hospital
Bruce M Psaty - Kaiser Permanente Washington Health Research Institute
Danish Saleheen - Center for Non-Communicable Diseases
Kari Stefansson - University of Iceland
Eric Boerwinkle - Baylor College of Medicine
Daniel I Chasman - Harvard Medical School
Daniel Levy - National Heart Lung and Blood Institute
Christopher Newton-Cheh - Massachusetts General Hospital
Patricia B Munroe - Queen Mary University of London
Joanna M M Howson - Novo Nordisk
EPIC-InterAct
Publication Details: Nature genetics, Vol.52(12), pp.1314-1332
Grant note: MC_UU_00026/3 / Medical Research Council R01 DK062370 / NIDDK NIH HHS MR/N003284/1 / Medical Research Council R21 HL123677 / NHLBI NIH HHS R01 DK072193 / NIDDK NIH HHS R01 DK107786 / NIDDK NIH HHS G0800270 / Medical Research Council 090532 / Wellcome Trust PG/17/35/33001 / British Heart Foundation MR/L01341X/1 / Medical Research Council MR/S004068/2 / Medical Research Council P50 HD028138 / NICHD NIH HHS MC_PC_U127592696 / Medical Research Council MR/S003746/1 / Medical Research Council MC_UU_12015/1 / Medical Research Council 106130 / Wellcome Trust R01 DK117445 / NIDDK NIH HHS R01 DK101855 / NIDDK NIH HHS RG/18/13/33946 / British Heart Foundation MC_UU_12013/2 / Medical Research Council PG/19/16/34270 / British Heart Foundation T32 CA160056 / NCI NIH HHS K12 HD043483 / NICHD NIH HHS MC_UU_00002/7 / Medical Research Council 268834 / European Research Council G0401527 / Medical Research Council Wellcome Trust R01 HL120393 / NHLBI NIH HHS MC_PC_MR/R020183/1 / Medical Research Council MC_UU_00006/1 / Medical Research Council R01 DK110113 / NIDDK NIH HHS R21 HL140385 / NHLBI NIH HHS MR/R023484/1 / Medical Research Council RE/18/6/34217 / British Heart Foundation 202802/Z/16/Z / Wellcome Trust NF-SI-0617-10090 / Department of Health 14136 / Cancer Research UK MR/S004068/1 / Medical Research Council MC_U106179471 / Medical Research Council SP/09/002 / British Heart Foundation G9521010 / Medical Research Council MC_UU_00007/10 / Medical Research Council U01 HG007417 / NHGRI NIH HHS MC_UU_00011/4 / Medical Research Council R01 DK093757 / NIDDK NIH HHS 204623/Z/16/Z / Wellcome Trust MC_UU_00011/5 / Medical Research Council 203141 / Wellcome Trust RG/13/13/30194 / British Heart Foundation U01 HL120393 / NHLBI NIH HHS MR/L003120/1 / Medical Research Council R01 HL105756 / NHLBI NIH HHS U01 DK062370 / NIDDK NIH HHS 212259 / Wellcome Trust 098381 / Wellcome Trust MC_UU_00011/1 / Medical Research Council R01 MD012765 / NIMHD NIH HHS G1000143 / Medical Research Council RG/14/5/30893 / British Heart Foundation
Identifiers: 9935585008331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article