Abstract
Antimicrobial The aim of the present communication is to evaluate whether prediabetic state affects peri-implant health status? Several databases were searched from August 1975 up to August 2019 for studies that evaluated the clinical and radiographic peri-implant parameters including plaque index (PI), bleeding on probing (BOP), probing depth (PD), and crestal bone level (CBL) in patients with prediabetes and non-diabetes. The standard mean differences (SMD) of outcomes and 95% confidence intervals (CI) for each variable were calculated using random effect model. Quality assessment and risk of bias were estimated using ROBINS-I and GRADE. Six studies were included. An overall quality assessment showed low to moderate risk of bias. The overall weighted mean difference for PI (SMD=3.42, 95% CI= 0.67 to 6.17, P=0.015), BOP (SMD=6.69, 95% CI= 4.94 to 8.45, P<0.001), PD (SMD=7.77, 95% CI= 4.87 to 10.67, P<0.001) and CBL (SMD=6.87, 95% CI= 0.98 to 12.77, P=0.023) showed statistically significant differences between prediabetes and non-diabetic groups, respectively. The direction of recommendation emerging from this meta-analysis is strong in favour of prediabetes in the deterioration of peri-implant health compared to non-diabetic patients.