Does the initial surgery for necrotizing enterocolitismatter? Comparative outcomes for laparotomy vs. peritoneal drain as initial surgery for necrotizing enterocolitis in infants < 1000 g birth weight

Toby Debra Yanowitz; Kevin M. Sullivan; Anthony J. Piazza; Beverly Brozanski; Isabella Zaniletti; Jotishna Sharma; Robert DiGeronimo; Sujir Pritha Nayak; Rajan Wadhawan; Kristina M. Reber; Karna Murthy; Francine Dykes; Anthony Piazza; Gregory Sysyn; Carl Coghill; Allison Black; Ramasubbareddy Dhanireddy; Anne Hansen; Tanzeema Houssain; Gustave Falciglia; Beth Haberman; Breda Poindexter; Amy Nathan; Kristin Nelson; Paul Kingma; Stefanie Riddle; Stephanie Merhar; Heather Kaplan; Kristina Reber; Rashmin Savani; Luc Brion; Noorjahan Ali; Theresa Grover; Girija Natarajan; Jonathan Nedrelow; Annie Chi; Yvette Johnson; Gautham Suresh; William Engle; Lora Simpson; Gregory Sokol; Rebecca Rose; Eugenia Pallotto; Robert Lyle; Becky Rogers; Lisa Kelly; Steven Chin; Rachel Chapman; Jamie Limjoco; Lori Haack; David Durand; Jeanette Asselin; Art D'Harlingue; Priscilla Joe; Jacquelyn Evans; Michael Padula; David Munson; Suzanne Touch; Tasmin Najaf; Rakesh Rao; Amit Mathur; Victor McKay; Mark Speziale; Brian Lane; Laural Moyer; Billie Short; Kevin Sullivan; Con Yee Ling; Shrena Patel; Michael Uhing; Ankur Datta; Lynne Willett; Nicole Birge; Robert Digeronimo; Zeenia Billimoria; Kyong-Soon Lee; Michel Mikhael; Irfan Ahmad; CHND Surg NEC Focus Grp

doi:10.1016/j.jpedsurg.2018.12.010

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Does the initial surgery for necrotizing enterocolitismatter? Comparative outcomes for laparotomy vs. peritoneal drain as initial surgery for necrotizing enterocolitis in infants < 1000 g birth weight

Journal article

Peer reviewed

Does the initial surgery for necrotizing enterocolitismatter? Comparative outcomes for laparotomy vs. peritoneal drain as initial surgery for necrotizing enterocolitis in infants < 1000 g birth weight

Toby Debra Yanowitz, Kevin M. Sullivan, Anthony J. Piazza, Beverly Brozanski, Isabella Zaniletti, Jotishna Sharma, Robert DiGeronimo, Sujir Pritha Nayak, Rajan Wadhawan, Kristina M. Reber, …

Journal of pediatric surgery, Vol.54(4), pp.712-717

01/04/2019

DOI: https://doi.org/10.1016/j.jpedsurg.2018.12.010

PMID: 30765157

Abstract

Life Sciences & Biomedicine

Pediatrics

Science & Technology

Surgery

Purpose: Quantify short-term outcomes associated with initial surgery [laparotomy (LAP) vs. peritoneal drain (PD)] for necrotizing enterocolitis (NEC) in extremely-low-birth-weight (ELBW) infants. Methods: Using the Children's Hospitals Neonatal Database, we identified ELBW infants <32 weeks' gestation with surgical NEC (sNEC). Unadjusted and multivariable regression analyses were used to estimate the associations between LAP (or PD) and death/short bowel syndrome (SBS) and length of stay (LOS). Results: LAP was the more common initial procedure for sNEC (n = 359/528, 68%). Infants receiving LAP were older and heavier. Initial procedure was unrelated to death/SBS in both bivariate (LAP: 43% vs PD: 46%, p = 0.573) and multivariable analyses (OR = 0.89, 95% CI=0.57, 1.38, p = 0.6). LAP was inversely related to mortality (29% vs. 41%, p < 0.007) in bivariate analysis, but not significant in multivariable analysis accounting for markers of preoperative illness severity. However, the association between LAP and SBS (14% vs. 5%, p = 0.012) remained significant in multivariable analyses (adjusted OR = 2.25, p = 0.039). LOS among survivors was unrelated to the first surgical procedure in multivariable analysis. Conclusion: ELBW infants who undergo LAP as the initial operative procedure for sNEC may be at higher risk for SBS without a clear in-hospital survival advantage or shorter hospitalization. (c) 2019 Elsevier Inc. All rights reserved.

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Title: Does the initial surgery for necrotizing enterocolitismatter? Comparative outcomes for laparotomy vs. peritoneal drain as initial surgery for necrotizing enterocolitis in infants < 1000 g birth weight
Creators - without role: Toby Debra Yanowitz - University of Pittsburgh
Kevin M. Sullivan - Thomas Jefferson University
Anthony J. Piazza - Emory University
Beverly Brozanski - University of Pittsburgh
Isabella Zaniletti - Children's Hospital Association
Jotishna Sharma - University of Missouri–Kansas City
Robert DiGeronimo - University of Washington
Sujir Pritha Nayak - The University of Texas Southwestern Medical Center
Rajan Wadhawan - University of Central Florida
Kristina M. Reber - The Ohio State University
Karna Murthy - Northwestern Univ, Chicago, IL;
Francine Dykes - Childrens Healthcare Atlanta, Atlanta, GA USA
Anthony Piazza - Emory University
Gregory Sysyn - Scottish Rite Freemasonry
Carl Coghill - Childrens Hosp Alabama, Birmingham, AL USA
Allison Black - Childrens Hosp Alabama, Birmingham, AL USA
Ramasubbareddy Dhanireddy - Le Bonheur Childrens Hosp, Memphis, TN USA
Anne Hansen - Childrens Hosp Boston, Boston, MA USA
Tanzeema Houssain - Childrens Hosp Boston, Boston, MA USA
Gustave Falciglia - Ann & Robert H Lurie Childrens Hosp Chicago, Chicago, IL USA
Beth Haberman - Cincinnati Childrens Hosp, Cincinnati, OH USA
Breda Poindexter - Cincinnati Childrens Hosp, Cincinnati, OH USA
Amy Nathan - Cincinnati Childrens Hosp, Cincinnati, OH USA
Kristin Nelson - Cincinnati Childrens Hosp, Cincinnati, OH USA
Paul Kingma - Cincinnati Childrens Hosp, Cincinnati, OH USA
Stefanie Riddle - Cincinnati Childrens Hosp, Cincinnati, OH USA
Stephanie Merhar - Cincinnati Childrens Hosp, Cincinnati, OH USA
Heather Kaplan - Cincinnati Childrens Hosp, Cincinnati, OH USA
Kristina Reber - The Ohio State University
Rashmin Savani - College Station Medical Center
Luc Brion - College Station Medical Center
Noorjahan Ali - College Station Medical Center
Theresa Grover - Childrens Hosp Colorado, Aurora, CO USA
Girija Natarajan - Childrens Hosp Michigan, Detroit, MI 48201 USA
Jonathan Nedrelow - Cook Childrens Hlth Care Syst, Ft Worth, TX USA
Annie Chi - Cook Childrens Hlth Care Syst, Ft Worth, TX USA
Yvette Johnson - Cook Childrens Hlth Care Syst, Ft Worth, TX USA
Gautham Suresh - Texas Childrens Hosp, Houston, TX 77030 USA
William Engle - Riley Childrens Hosp, Indianapolis, IN USA
Lora Simpson - Riley Childrens Hosp, Indianapolis, IN USA
Gregory Sokol - Riley Childrens Hosp, Indianapolis, IN USA
Rebecca Rose - Riley Childrens Hosp, Indianapolis, IN USA
Eugenia Pallotto - Sisters of Mercy Health System
Robert Lyle - Arkansas Childrens Hosp, 800 Marshall St, Little Rock, AR 72202 USA
Becky Rogers - Arkansas Childrens Hosp, 800 Marshall St, Little Rock, AR 72202 USA
Lisa Kelly - Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA
Steven Chin - Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA
Rachel Chapman - Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA
Jamie Limjoco - Amer Family Childrens Hosp, Madison, WI USA
Lori Haack - Amer Family Childrens Hosp, Madison, WI USA
David Durand - Childrens Hosp & Res Ctr Oakland, Oakland, CA USA
Jeanette Asselin - Childrens Hosp & Res Ctr Oakland, Oakland, CA USA
Art D'Harlingue - Childrens Hosp & Res Ctr Oakland, Oakland, CA USA
Priscilla Joe - Childrens Hosp & Res Ctr Oakland, Oakland, CA USA
Jacquelyn Evans - Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
Michael Padula - Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
David Munson - Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
Suzanne Touch - St Christophers Hosp Children, Philadelphia, PA 19133 USA
Tasmin Najaf - St Louis Childrens Hosp, St Louis, MO 63178 USA
Rakesh Rao - St Louis Childrens Hosp, St Louis, MO 63178 USA
Amit Mathur - St Louis Childrens Hosp, St Louis, MO 63178 USA
Victor McKay - All Childrens Hosp, St Petersburg, FL USA
Mark Speziale - Rady Childrens Hosp, San Diego, CA USA
Brian Lane - Rady Childrens Hosp, San Diego, CA USA
Laural Moyer - Rady Childrens Hosp, San Diego, CA USA
Billie Short - College Station Medical Center
Kevin Sullivan - Thomas Jefferson University
Con Yee Ling - College Station Medical Center
Shrena Patel - College Station Medical Center
Michael Uhing - Childrens Hosp Wisconsin, Milwaukee, WI 53201 USA
Ankur Datta - Childrens Hosp Wisconsin, Milwaukee, WI 53201 USA
Lynne Willett - Childrens Hosp Omaha, Omaha, NE USA
Nicole Birge - Childrens Hosp Omaha, Omaha, NE USA
Robert Digeronimo - University of Washington
Zeenia Billimoria - Seattle Childrens Hosp, Seattle, WA USA
Kyong-Soon Lee - Sick
Michel Mikhael - Childrens Hosp Orange Cty, Los Angeles, CA USA
Irfan Ahmad - Childrens Hosp Orange Cty, Los Angeles, CA USA
CHND Surg NEC Focus Grp
Publication Details: Journal of pediatric surgery, Vol.54(4), pp.712-717
Publisher: Elsevier
Number of pages: 6
Grant note: Cincinnati Children's Hospital, Cincinnati, OH Children's Hospital Boston, Boston, MA St. Christopher's Hospital for Children, Philadelphia, PA Children's Hospital of Michigan, Detroit, MI Children's Hospital of Omaha Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA Le Bonheur Children's Hospital, Memphis, TN St. Louis Children's Hospital, St Louis, MO Nationwide Children's Hospital, Columbus, OH Rady Children's Hospital, San Diego, CA Seattle Children's Hospital, Seattle, WA Children's Healthcare of Atlanta, Atlanta, GA Children's Hospital of Alabama, Birmingham, AL Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL Children's Medical Center, Dallas, TX American Family Children's Hospital, Madison, WI Children's Healthcare of Atlanta at Scottish Rite Children's Hospital Los Angeles, Los Angeles, CA Children's Hospital of Philadelphia, Philadelphia, PA Primary Children'sMedical Center, Salt Lake City, UT Children's Hospital & Research Center Oakland, Oakland, CA Children's Mercy Hospitals & Clinics, Kansas City, MO All Children's Hospital, St. Petersburg, FL Children's National Medical Center, Washington, DC Children's Hospital Orange County, Los Angeles, CA Children's Hospital Colorado, Aurora, CO Cook Children's Health Care System, Fort Worth, TX Arkansas Children's Hospital, Little Rock, AR AI DuPont Hospital for Children, Wilmington, DE Children's Hospital of Wisconsin, Milwaukee, WI Hospital for Sick Children, Toronto, ON Texas Children's Hospital, Houston, TX Riley Children's Hospital, Indianapolis, IN
Identifiers: 9923311508331
Academic Unit: King Khalid University
Language: English
Resource Type: Journal article