Abstract
Given the shortage of available organs for clinical transplantation, much recent research has been directed towards the possibility of using organs from animals in human replacement therapy. Such "xenografting" would be highly desirable in that it would provide a large pool of organs for transplantation but the severity of rejection observed in cross-species transplantation means that significant advances in recipient immunosuppression will be required before successful clinical use. To date, no recipient immunosuppressive regime has proved successful in allowing long-term survival of a xenografted organ. For this reason, it was intended to investigate the effects of a pretreatment protocol (previously shown to be effective in prolonging survival of allografts in recipients given subtherapeutic cyclosporine (CyA)).