Sign in
Back
Double-headed Acyclo C-Nucleoside Analogues. Functionalized 1,2-bis-(1,2,4-Triazol-3-yl)ethane-1,2-diol
Journal article   Peer reviewed

Double-headed Acyclo C-Nucleoside Analogues. Functionalized 1,2-bis-(1,2,4-Triazol-3-yl)ethane-1,2-diol

A. H. Moustafa, R. A. Haggam, M. E. Younes and E. S. H. El Ashry
Nucleosides, nucleotides & nucleic acids, Vol.24(10-12), pp.1885-1894
01/09/2005
DOI: https://doi.org/10.1080/15257770500268962
PMID: 16438055

Abstract

1,2,4-Triazolo-[3,4-b][1,3,4]-thiadiazine 1,2,4-Triazolo[3,4-b][1,3,4]thiadiazole Acyclonucleoside Ethane-1,2-diol L-Tartaric acid
Reaction of L-tartaric acid with thiocarbohydrazide afforded (1R, 2S)-1,2-bis(4-amino-5-mercapto-1,2,4-triazol-3-yl)-ethane-1,2-diol (3). The functional groups in 3 allowed the construction of fused heterocycles on the 1,2,4-triazole rings, mainly of the 1,2,4-triazolo[3,4-b][1,3,4]thiadiazine type as in 4, 5, 7, 10, 13 and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole type as in 14.

Metrics

1 Record Views

Details