Abstract
Controlling blood sugar levels is crucial for diabetic patients and is managed through administration of drugs such as gliquidone. Coadministration of antidiabetic drugs with H-1-receptor antagonists is common but is also a source of concern due to potential coadministered drug interaction, especially in patients prone to allergic disorders. In this work, we describe in vitro drug interactions of gliquidone with commonly coadministered H-1-receptor antagonists (fexofenadine hydrochloride, cetirizine dihydrochloride, and levocetirizine dihydrochloride). These studies were performed at 37A degrees C in different pH environments simulating human body compartments using UV spectrophotometry and high performance liquid chromatography (HPLC). It was observed that the percentage availability values of gliquidone and H-1-receptor antagonists were not affected in the presence of each other. No significant difference between gliquidone and H-1-receptor antagonists and no remarkable changes in availability values were observed when these interactions were studied using UV-visible and HPLC techniques. This study thus supports the safe coadministration of gliquidone and H-1-receptor blockers as an effective diabetic health management regimen.