Abstract
The present work is aimed to study the interactions between cefpirome and hypoglycemic agents (gliquidone, metformin, and pioglitazone) by chromatographic and spectroscopic techniques. In the first case, reversed-phase high-performance liquid chromatographic methods have been developed, validated for the simultaneous determination of cefpirome with hypoglycemic agents, and was applied for interaction studies. These interactions were carried out in simulated gastric juice (pH1), buffers of pH 4, 7.4, and 9 at 37 A degrees C for 3 h. In the second case, cefpirome-hypoglycemic agents complexes were synthesized and elucidated on the basis of FT-IR, H-1-NMR, and C-13-NMR studies.