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Dye labelling of nucleosides
Journal article   Peer reviewed

Dye labelling of nucleosides

Alan R Katritzky, Levan Khelashvili, Judit Kovacs and Karem Shanab
Chemical biology & drug design, Vol.73(4), pp.396-402
04/2009
DOI: https://doi.org/10.1111/j.1747-0285.2009.00792.x
PMID: 19291102

Abstract

Amino Alcohols - chemical synthesis Amino Alcohols - chemistry Azo Compounds - chemical synthesis Azo Compounds - chemistry Butylene Glycols - chemical synthesis Butylene Glycols - chemistry Coloring Agents - chemical synthesis Coloring Agents - chemistry Magnetic Resonance Spectroscopy Nucleosides - chemical synthesis Nucleosides - chemistry Staining and Labeling - methods Triazoles - chemical synthesis Triazoles - chemistry
Dye-labelled nucleosides were obtained in 30-79% (average 45%) yields by treating N-(4-arylazobenzoyl)-1H-benzotriazoles 3a-b with appropriate nucleosides. Similarly, 3a-b afforded dye-labelled threoninol conjugates in 55-89% (average 67%) yields. All novel products were characterized by NMR and elemental analysis.

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