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E- and chemoselective thia-Michael addition to benzyl allenoate
Journal article   Peer reviewed

E- and chemoselective thia-Michael addition to benzyl allenoate

Rifhat Bibi, Amna Murtaza, Khalid Mohammed Khan, Zia ur Rehman, Aamer Saeed, Muhammad Nawaz Tahir and Abbas Hassan
Phosphorus, sulfur, and silicon and the related elements, Vol.195(12), pp.969-975
28/07/2020

Abstract

chemoselective E-selective Thia-Michael addition α-β-unsaturation β-substituted thioenoates
Different thiols were successfully reacted with benzyl allenoate resulting in E-selective thia-Michael addition product with α,β-unsaturation as confirmed by single crystal x-ray crystallographic analysis. The thia-Michael addition is chemoselective and free amine and alcohol groups were well tolerated. Catalytic triethylamine was required for high conversion. Fair to excellent yields were obtained for a variety of aliphatic, aryl and heteroaryl thiols.

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