Abstract
The most common neurological brain issue is Alzheimer's disease, which can be diagnosed using a variety of clinical methods. However, the electroencephalogram (EEG) is shown to be effective in detecting Alzheimer's disease. The purpose of this research is to develop a computer-aided diagnosis system that can diagnose Alzheimer's disease using EEG data. In the present study, a band-pass elliptic digital filter was used to eliminate interference and disturbances from the EEG dataset. Next, the Discrete Wavelet Transform (DWT) technique has been employed to decompose the filtered signal into its frequency bands in order to extract the features of EEG signals. Then, different signal features such as logarithmic band power, standard deviation, variance, kurtosis, average energy, root mean square, and Norm have been integrated into the DWT technique to generate the feature vectors and improve the diagnosis performance. After that, nine machine learning approaches have been investigated to classify EEG features into their corresponding classes: linear discriminant analysis (LDA), quadratic discriminant analysis (QDA), support vector machine (SVM), Naïve bayes (NB), k-nearest neighbor (KNN), decision tree (DT), extreme learning machine (ELM), artificial neural network (ANN), and random forests (RF). Finally, the performance of the different proposed machine learning approaches have been compared and evaluated by computing the sensitivity, specificity, overall diagnosis accuracy, and area under the receiver operating characteristic (ROC) curves and plotting the ROC curves and confusion matrices for five classification problems. These investigations aim to compare the proposed approaches and recommend the best combination method for the diagnosis of Alzheimer's disorders. According to the results, the KNN classifier achieved an average classification accuracy of 99.98% with an area under the ROC curve of 100%. Our findings show that the suggested methodologies are an appealing supplementary tool for identifying possible biomarkers to help in the clinical diagnosis of Alzheimer's disease.