Abstract
The effect of various levels of effervescent salt on the release of fenoprofen calcium and ketoprofen from hard gelatin capsules prepared under three compression forces was studied The disintegrants, explotab and avicel were also employed to prepare capsules under the same conditions for comparison. In case of effervescent salt, the maximum effectiveness was obtained at low compression pressure. The rate of drug release was markedly increased as the concentration of effervescent salt increased. In case of disintegrants, the maximum effectiveness was obtained at higher compression pressure. At low compression pressure high level of disintegrant was required to accelerate the disintegration and drug release. The urinary excretion bioavailability of ketoprofen capsules indicated that 10 % of effervescent salt or disintegrant gave a marked increase in its bioavailability specially from dicalcium phosphate-based capsules, where the bioavailability was increased from 66.22 % to 81.38 %. A significant in vivo-in vitro correlation was obtained by plotting either the bioavailability percent against Ln T50 % dissolution or the mean cumulative amount excreted after 2 h against 30 min dissolution data.