Abstract
Inhibition of acetylcholinesterase (AChE) in the whole brain, cerebellum, pens, frontal cortex, basal ganglia and medulla oblongata of mt brain by physostigmine (GAS 57-47-6) in vitro was studied. Constants characterizing this inhibition namely: binding constant (K-I) and bimolecular rate constant (K'(2)) were determined The highest values of K'(2) were obtained in the cases of pens and medulla oblongata, the parts responsible for the respiratory and vital centers. The difference in the inhibition of AChE in the different parts of the brain could be due to the difference in the grey and white matters contents in these parts.