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EFFECTIVE SYNTHESIS OF 1,5-DISUBSTITUTED 2,1-BENZISOTHIAZOL-3(1H)-ONES
Journal article   Peer reviewed

EFFECTIVE SYNTHESIS OF 1,5-DISUBSTITUTED 2,1-BENZISOTHIAZOL-3(1H)-ONES

Rajendra K. Kharul, Pinkal N. Prajapati, Amol A. Thorave, Hardik A. Shah, Arghya Dhar, Darshan A. Joshi, Mukul R. Jain, Pankaj R. Patel and S. S. Pancholi
Synthetic communications, Vol.41(22), pp.3265-3279
15/11/2011
DOI: https://doi.org/10.1080/00397911.2010.515343

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
A convenient and effective synthesis of novel 1,5-disubstituted 2,1-benzisothiazol-3(1H)-one derivatives is described. The approach involves nitration of inexpensive isatoic anhydride followed by its conversion to 5-nitro-2,1-benzisothiazol-3(1H)-ones in excellent yield and alkylation at the 1-position. The 5-amino group was further derivatized.

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