Abstract
Infection of the dental pulp will cause inflammation and at some point, tissue necrosis which is dealt with traditionally by pulpectomy and root canal treatment. Advances in regenerative medicine and tissue engineering together with the introduction of new sources of stem cells have resulted in the opportunity of pulp tissue regeneration. In this review we discuss about stem cell sources and their usage in medicine and specifically in dental field. We conducted a literature review of articles published up to 2018, in following databases; PubMed, and Embase overviewing the dental pulp stem cells in pulp regeneration treatment. It is essential to recognize that endodontic therapy of teeth with necrotic pulp using stem cells as well as appropriate biomaterials lead to pulp regeneration. Nevertheless, feasibility of stem cell transplantation to therapy sites together with its cost might be challenges for medical use of such methods. Scafolds and biomaterials supply a purposeful strategy to far better include stem cells and development factors in addition to regulated rate of regeneration. As a result, we recommend future studies to concentrate on providing a clear guideline for appropriate as well as better features of biomaterials to be made use of in regenerative endodontics.