Abstract
One of the main causes of morbidity and mortality worldwide is diabetes mellitus. The present study aims to evaluate the effect of olive leaf extract on lipid profile and heart function enzymes in model type two diabetes mellitus (T2DM) induced by streptozotocin (STZ) in rats. Healthy Wistar male adult rats were randomly divided into four equal groups; normal control, diabetic control (45 mg/kg STZ), normal rats treated with olive leaf extract (17.8 mg/kg b.wt.) and diabetic rats treated with olive leaf extract. Olive leaves extract was orally administrated for 10 weeks. Total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL), lactate dehydrogenase (LDH), creatine kinase, and a-amylase were analyzed at zero time and after 10 weeks. Olive leaf extract exerted a positive effect on lipid profile via reducing TC, TG and LDL in addition, significantly preventing of the decrease in HDL. LDH and creatine kinase were also kept close to normal in diabetic rats that received olive leaves extract. Prevention of a-amylase reduction was also observed. The present study suggests that, olive leaves extract could be used safely to prevent T2DM complications such as cardiovascular diseases through ameliorating glycemic state and lipids profile.