Abstract
Epidermolysis bullosa (EB) encompasses a clinically and genetically heterogeneous group of rare inherited disorders characterized by marked mechanical fragility of epithelial tissues with blistering and erosions following even minor trauma. [1] In addition, young adults with the classic form of dystrophic epidermolysis bullosa have a very high risk of developing squamous cell carcinoma (SSC), a form of skin cancer that tends to be usually aggressive and often is life-threatening. [2] Patients with epidermolysis bullosa and SCC are uncommon and present a clinical challenge because of limited options for wound coverage and SCCs frequent recurrence. Therefore, we provide this case report to emphasize the importance of vigilance in surveying epidermolysis bullosa patients for their increased risk of developing SCC and performing a biopsy and managing the condition early.