Abstract
Inflammation and dyskinesia of the gallbladder without evidence of calculi is known as acute acalculous cholecystitis (AAC) and can lead to high complications or death. AAC due to autoimmune hepatitis (AIH) is very rare. Options of therapy can be chosen according to the condition of the patient and the underlying cause of AAC. Early diagnosis and intervention have a positive effect on clinical outcome. Here, we presented an adult female patient diagnosed with AIH complicated with AAC. Her symptoms improved following the successful combination therapy of corticosteroids and immunosuppressive agents for AIH without any complications and may even be adequate for AAC by avoiding surgical interventions.