Abstract
Eco-friendly, low-cost and high-yielding synthetic route toward imidazoles and oxazoles has been developed. 1-(4,6-Dimethylpyrimidin-2-yl)-2-(alkylamino)-1,5-dihydro-4
H
-imidazol-4-one
3a–c
have been synthesized via regiospecific reaction of ethyl 2-(
N
-(4,6-dimethylpyrimidin-2-yl)cyanamide)acetate
1
with primary aliphatic amines in water as green solvent. While, the reaction between 4,6-dimethylpyrimidin-2-yl(2-oxo-2-phenylethyl)cyanamide
2
and primary aliphatic amines using water and/or
iso
-propanol as green solvents afforded 3-(4,6-dimethylpyrimidin-2-yl)-5-phenyl-1,3-oxazole-2(3
H
)-imine
6
and 1-(4,6-dimethylpyrimidin-2-yl)-
N
-alkyl-4-phenyl-1
H
-imidazol-2-amine
7a–d
, respectively.
Graphical abstract