Abstract
Green organic synthesis is needed to face current environmental pollution. Many synthetic approaches have been developed to produce substituted cyanopyridines. However, only a few green methods are reported. This article reports a simple and convenient synthesis of substituted pyridines by one-pot multi-component reaction of 1,3-dicarbonyl compounds, aromatic aldehydes, malononitrile and alcohols, catalyzed by doped animal bone meal as catalyst. The reaction has several advantages such as high yields of 80–92 %, short reaction times of 10–15 min, easy purification processes and methodological simplicity.