Abstract
The study objective was to evaluate
Allium sativum's
potential and
Nigella Sativa's
combination's potential to reduce aluminum toxicity and return to the normal state. In the present study, a hundred albino rats were randomly divided into five equal groups. The first group was used as a control group; the other four groups were exposed to aluminum 1,600 ppm. The second exposed to aluminum only; the third and fourth groups were treated with
Allium sativum
5% and
Nigella sativa
5%, respectively, while the fifth group was treated with a mix of
Allium sativum
2.5% and
Nigella sativa
2.5% for 8th weeks. After 8 weeks, the aluminum administration was stopped, and the second group was divided into three groups. The groups were treated with
Allium sativum
5% and
Nigella sativa
5%, and a mix of
Allium sativum
2.5% and
Nigella sativa
2.5%, respectively. The first group was the control group (continued from the first experiment). Garlic and
Nigella sativa
were crushed and added to feed while receiving aluminum chloride daily at a dose of 1.6 ml/l was added to the drinking water. Histopathological changes in the liver, kidney, and testes were investigated after 8 and 16 weeks, and blood samples were collected after 4, 8, and 16 weeks for biochemical blood parameters. The results showed that the histopathological examination of the liver, kidney, and testes showed signs of congestion in blood vessels after aluminum exposure. Meanwhile, the treatment with
Allium sativum
or
Nigella sativum
or the mixture between them had positive effects on evading the harmful effects of aluminum in the liver, Kidney, and testes tissues. In addition, there were protective effects for
Allium sativum
and
Nigella sativa
against aluminum on serum creatinine, urea, ALT, and AST concentrations. The present study concluded that supplementation
with Allium sativum
or
Nigella sativa
or their combination could reduce aluminum toxicity and return the liver, kidney, and testes to normal.