Abstract
OBJECTIVE: To assess the effect of methanol extract of Ajwain on coagulation parameters PT and aPTT and to determine usefulness.
DESIGN: This comparative study was conducted in the Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Pakistan.
METHODS: Antithrombotic tests PT and aPTT were conducted after multiple dosing of Ajwain on rats using standard kits and reagents, which were performed on Humaclot duo Germany. The data was subjected to analysis by taking mean and standard error to the mean using student T-test.
RESULTS: The results revealed that Ajwain extract did not show any significant effect on aPTT whereas increase in PT was highly significant (P < 0.001).
CONCLUSION: The results suggested that the methanol extract of Ajwain prolonged PT, similar to that of Warfarin suggesting its possible effects on the extrinsic pathway, while aPTT was not altered suggesting that it may have no effects on the intrinsic pathway.