Abstract
Adipocytokines have been implicated in the pathogenesis and metabolic complications of diabetes mellitus. Camel milk (CM) is gaining increasing recognition, due to its beneficial effects, in patients with the diabetes. The aim of the current study is to investigate the effects of CM on adipocytokines levels in children with type 1 diabetes mellitus (T1D). Thirty children with type 1 diabetes were selected from the Diabetic Endocrine Metabolic Pediatric Unit, children hospital, Cairo University. Measurements of HbA1c, lipid profile, superoxide dismutase (SOD), Interleukin-1 beta (IL-1 beta), IL6, IL18 and lipocalin-2 levels were done at beginning and one month after consumption of CM daily. Thirty Healthy children with matched age and sex serve as control group. The baseline levels of lipid profile and HbA1c showed a significant improvement after CM consumption. Serum levels of IL-1 beta, IL-6, IL-18, lipocalin 2 in type ldiabetes post-treatment group were significantly decreased compared with pre-treatment group (P <= 0.001). Camel milk has a unique composition that is rich in insulin. It exerts immunomodulatory effects. Regular consumption of CM could provide a natural way to improve glycemic control with a significant reduction in lipids in diabetic patients.