Abstract
Cadmium Chloride (CdCl2) can accumulate in kidneys as a toxic metal and cause renal failure. This study was undertaken to evaluate the protective effects of Terminalia chebula fruit extract against CdCl2-induced renal failure in rats. Forty male albino rats, of 185 +/- 20 g weight, were assigned into five groups (n = 8 each). All groups fed on basal diet. The primary group was negative control group (-ve). Other four groups were administrated CdCl2 (3 mg/kg bw). One of them was served as a positive control group (+ve) and three groups were treated with orally T. chebula extract (200, 300, and 400 mg/kg/day), respectively for 28 days. The results indicated that treatment with T.chebula fruit extract helpful to alleviate the CdCl2 induced toxicity in kidney by significantly decreased levels of serum uric acid, urea creatinine, and total protein. Oral administration of T.chebula fruit extract with (200, 300, and 400 mg/kg/day) to nephrotoxicity rats were showed brought back in serum lipid profiles and hepatic biomarkers, tissue lipid peroxidation (LPO) enzymatic, and non-enzymatic antioxidants to near normal. Moreover, the histological evaluation of kidney approved the amelioration of the previous parameters. In conclusion, the present study suggests that the treatment with T.chebula fruit extract is helpful in alleviation the renal injury induced by CdCl2