Abstract
Cloud point (CP) measurements of 4-(1,1,3,3-tetramethylbutyl) phenyl-polyethyleneglycol (Triton X-100 (TX-100)) were performed in aqueous solution in the presence of drug Amikacin sulfate (AS)/Neomycin sulfate (NS)/(AS/NS+ different inorganic salts). In aqueous solution, the CP values of TX-100 first decrease with increasing concentration and then increase with increasing surfactant concentration. The CP values of TX-100 solutions were found to increase with the increasing concentration of the AS/NS drug. The CP values of TX-100-AS/NS mixtures were also observed to decrease with the increase of the concentration of salt. Different thermodynamic parameters such as standard free energy (Delta Gc0), standard enthalpy (Delta Hc0) as well as the standard entropy (Delta Sc0) change of phase separation were calculated and discussed in relation to molecular interactions.