Abstract
The effect of acetylsalicylic acid and phenylbutazone on the intestinal absorption of glucose in vitro has been studied. Incubation of the rat everted intestine in a modified Krebs bicarbonate solution containing either acetylsalicylic acid or phenylbutazone resulted in an inhibition of active glucose transport, as well as an increase in the utilization and/or storage of the sugar. On a molar basis, phenylbutazone was shown to have a greater effect on glucose absorption than acetylsalicylic acid. The results are discussed with an attempt to explain some of the systemic effects of these drugs.