Abstract
Recently, nanotechnology plays a significant role in cancer prohibition and treatment. Various kinds of iron oxide are naturally occurring and may be synthesized under laboratory conditions. This research was intended to estimate the histological and biochemical changes induced by Ehrlich Solid Carcinoma (ESC) in the skeletal muscle of mice treated with Epirubicin, and Fe3O4/MPA NPs with hyperthermia. The experimental animals were equally allocated into 4 groups (50 mice/group). Mice of the first group were benefit as normal control. The second group were intramuscularly injected with ESC. The ESC affected mice of the third and fourth groups were treated with Epirubicin and Fe3O4 /MPA NPs with hyperthermia, respectively. The present investigations displayed that treatment of ESC mice with Epirubicin and Fe3O4 NPs/MPA revealed a significant reduce (P <= 0.05) in the creatinine kinase (CK), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activity. The histological changes in the skeletal muscles in the first treated group showed reduction of cancer cells, cirrhosis and destruction of tissue cells, also, the group administrated by Fe3O4/MPA with hyperthermia showed disappearance of a large number of cancer cells compared to the first group of treatment and the return of life to the fabric affected without touching or affecting the normal cells of the tissue. In conclusion, the in vivo cancer treatment test could cure the cancer tumor, protecting the skeletal muscle tissues and ameliorated CK, AST and ALT enzyme activity.