Abstract
Salvia triloba L. belongs to the Lamiaceae family, is one in all the vital medicinal plant species. This work aims to study the antioxidant related effects of S. triloba in the human body through in vivo study and the effects on liver, kidney, and heart function tests. For five days, nine healthy participants consumed 250 ml of S. triloba aqueous extract orally. Blood samples were taken before and one hour after the first dosage of water extract (samples I and II, respectively), and again one day after the last dose (i.e., day 6, sample III). Before the first dosage, the first blood sample was taken (i.e., sample I) and was used as a control for the subsequent II and III samples. Subsequent determinations were performed: serum total antioxidant status (TAS), red blood cell reduced glutathione (RBC GSH), red blood cell superoxide dismutation (RBC SOD) activity, red blood cell malondialdehyde (RBC MDA), and serum-selected biochemical tests. After 5 days of oral administration of S. triloba extract in healthy volunteers, serum TAS, erythrocyte GSH and erythrocyte SOD activity were significantly increased, and had no influence on serum biochemical examinations of kidney, liver, heart, pancreas, etc., contrasted with zero-time dose. S. triloba extract has effective antioxidation related effects in vivo. Because these findings were obtained in healthy people without oxidative stress, it means that S. triloba will enhance the defense system against probable oxidative damage and might be useful in avoiding pathological diseases related to oxidative damage.