Abstract
The hypothesis for the present work is proposed to explore the spherical crystallization technique for improving the micromeritics, compactability, and solubility characteristics of oxcarbazepine (OXZ), an anticonvulsant drug. Agglomerates containing different polymers (PEG 6000 and PVP K30) and process parameters were investigated for the enhancement of overall physicochemical performance and dissolution. Water, dichloromethane, and chloroform were used as a poor solvent, good solvent, and bridging liquid, respectively. Pure OXZ and spherical agglomerates were characterized for several properties including Fourier transformation-infrared spectroscopy, Differential scanning calorimetry, Scanning electronic microscopy, X-ray powder diffraction analysis, micromeritics, solubility studies, and in-vitro drug release kinetics. From the results, a considerable improvement in drug solubility and micromeritics of agglomerates than pure OXZ was observed. Compressibility parameters assessed from the Heckel plot showed agglomerates with a polymer having a higher value of slope (k) and less MyP is accountable for plastic deformation in agglomerates. Prepared spherical agglomerates showed an enhancement in solubility and rate of dissolution, which might improve their bioavailability.
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