Abstract
Two new flavonoid glycosides, kaempferol 3-O-alpha-L-rhamnopyranosyl (1 -> 6) (3"-acetyl)-(3-D-galactopyranoside 1 and kaempferol 3-O-alpha-Larabinopyranosyl-5-O-alpha-L-rhamnopyranoside 2, along with six known ones 3-8 were isolated from the flowers of Vicia faba L (Fabaceae). Methanol extract and the isolated compounds were tested against lipase and melanogenesis inhibition activities and resulted in that compound 2 showed 53 and 77% lipase inhibition activity in concentrations of 400 and 800 mu g/mL, respectively. For melanogenesis, compounds 2, 3 and 4 exhibited potent melanogenesis inhibition activity where the melanin content in melanoma cells was decreased to be about 57.5, 56 and 61%, respectively, with no obvious melanocytotoxicity.The rest of compounds showed weak to moderate activity. The results of melanogenesis inhibition activity of this study suggested the potential use of Vicia faba flowers as a skin-whitening agent and reveal the flowers to be a rich source of important phytochemicals with antilipase and melanogenesis inhibitory activity.
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