Abstract
OBJECTIVE: In recent years, in-creasing evidence suggests an association be-tween low Magnesium levels and type 2 diabetes mellitus. It has also been reported that the use of proton pump inhibitors may induce hypomag-nesemia. Although some case reports have de-scribed patients with Proton Pump Inhibitor -in-duced hypomagnesemia, the impact of Proton Pump Inhibitor use on hypomagnesemia has not been fully clarified in comparative studies. The objective of the study was to determine the Mag-nesium levels in patients with diabetes who are taking proton pump inhibitors and also to cor-relate the Magnesium levels in diabetic patients who take proton pump inhibitors with those not taking proton pump inhibitors.PATIENTS AND METHODS: A cross-sectional study was carried out in the study population com-prising adult patients attending internal medicine clinics in King Khalid Hospital, Majmaah, KSA. A total of 200 patients who gave informed consent were recruited into the study over one year.RESULTS: Overall prevalence of hypomag-nesemia was observed among 128 patients out of 200 (64%) diabetic patients. Relatively more patients with hypomagnesemia were found in group 2 (without PPI use) (38.5%) compared to group 1 (with PPI use) (25.5%). A statistically significant difference was not observed in group 1 using proton pump inhibitors and group 2 not using proton pump inhibitors (p-value = 0.473).CONCLUSIONS: Hypomagnesemia is seen in diabetic patients and patients who take proton pump inhibitors. There was no statistically sig-nificant difference in Magnesium levels in dia-betic patients, irrespective of proton pump in-hibitor use.