Abstract
The possible influence of coadministration of sucralfate on absorption of procainamide was assessed using salivary procainamide concentration. Four healthy volunteers participated in the study, in a randomized crossover fashion. Each subject was randomly assigned to receive either procainamide capsule alone (250 mg) or with sucralfate tablest (1 mg) ingested
1
2
h
before procainamide.
C
max was significantly decreased, but only by 5.3% when sucralfate was administered. There was no significant difference between the control and treatment studies for
t
max and AUC.