Abstract
The copper (II) complex of a simple pyridine- and amide-containing copolymer serves as an effective catalyst for heterogeneous hydrolysis of the prototypical phosphodiester bis(
p-nitrophenyl)phosphate at pH 8.0 and 25 °C with a first-order rate constant of
k
cat
=
8.3
×
10
−6 s
−1, corresponding to a catalytic proficiency of 75-thousand folds.
The copper (II) complex of a simple pyridine- and amide-containing copolymer serves as an effective catalyst for heterogeneous hydrolysis of the prototypical phosphodiester substrate bis(
p-nitrophenyl)phosphate at pH 8.0 and 25 °C. The catalysis has a first-order rate constant of
k
cat
=
8.3
×
10
−6 s
−1, corresponding to a catalytic proficiency of 75-thousand folds relative to the uncatalyzed hydrolysis with a rate constant of
k
0
=
1.1
×
10
−10 s
−1 in aqueous buffer solution at pH 8.0. This observation suggests that polymers can be designed to include various functional groups feasible for effective metal-centered catalysis of phosphodiester hydrolysis.