Abstract
Energy drinks (Red bull) is the most consumed in Saudi Arabia by different groups ages in recent times, especially by young age. It is one of the substances that cause many damages such as neurotoxicity, damage of nerve cells and impact on memory and learning difficulties. This study aims to determine the impact of oral administration of red bull on hippocampus tissue. 3.1 ml of red bull and saline (control) were daily administered orally for 3 weeks to rats. Neurotransmitters levelsincluding (Norepinephrine (NE), Dopamine (DA) and Gamma-AminobutyricAcids (GABA)) were measured and hippocampus tissues were used for histological assay. The result of the study showed that the levels of neurotransmitter were decreased in red bull administered rat. The histopathological findings of the hippocampus brain show that there were degeneration of nerve cells and nuclei, sharp abnormalities in pyramidal cells. This change will affect the memory.