Abstract
Sickle cell anemia (SCA) is a genetic disorder in the blood that is characterized by progressive organ malfunction, painful vaso-occlusive crises, and severe hemolytic anemia. This case-control aimed to compare study of this study is to determine the expression level of adhesion molecules: Vascular Cellular Adhesion Molecule-1 (VCAM-1), Intracellular Adhesion Molecule-1 (ICAM-1), Platelet selectin (P-selectin), and Endothelium selectin (E-selectin) in plasma samples using ELISA technique. This research included 78 males and females, 22 of whom were control individuals, and the rest were divided into 2 groups: steady-state sickle cell patients (SCA), and patients under hydroxyl-urea treatment (SCAHU). The study results indicated that plasma E- and P-selectin expression levels were significantly higher in the SCA group when compared to control groups, but there were no significant differences between the SCAHU and SCA groups for both E and P selectins. There was an increase in the ICAM-1 and VCAM-1 levels in the patient groups when compared to the control group, but they were not statistically significant. Our findings suggest that high expression of P-selectin, E-selectin, VCAM-1, and ICAM-1 predisposes patients to severe manifestations of SCA.
Disciplinary: Bioscience & Biochemistry, Medicine & Health Science, Biomedical and Biotechnology. (C) 2021 INT TRANS J ENG MANAG SCI TECH.