Abstract
The synergistic interactions between bile salts (BS) and the Pluronic block copolymer (P123) in aqueous solution at various mole fractions were investigated using the surface tension technique to explore the appropriate sequestrant (Pluronic P123) for bile salt. The interaction parameters in the bulk and surface were evaluated using ideal mixing and regular solution models. The synergistic effects operating in these amphiphile mixtures were confirmed by the negative values of the interaction parameter and reduction in critical micelle concentration (cmc) values. Energetic parameters computed for bile salts and block copolymer mixtures were also discussed in detail.