Effects of microbiota-directed foods in gnotobiotic animals and undernourished children

Jeanette Gehrig; Siddarth Venkatesh; Hao-Wei Chang; Matthew Hibberd; Vanderlene Kung; Jiye Cheng; Robert Chen; Sathish Subramanian; Carrie Cowardin; Martin Meier; David O'Donnell; Michael Talcott; Larry Spears; Clay Semenkovich; Bernard Henrissat; Richard Giannone; Robert Hettich; Olga Ilkayeva; Michael Muehlbauer; Christopher Newgard; Christopher Sawyer; Richard Head; Dmitry Rodionov; Aleksandr Arzamasov; Semen Leyn; Andrei Osterman; Iqbal Hossain; Munirul Islam; Nuzhat Choudhury; Shafiqul Sarker; Sayeeda Huq; Imteaz Mahmud; Ishita Mostafa; Mustafa Mahfuz; Michael Barratt; Tahmeed Ahmed; Jeffrey Gordon; Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

doi:10.1126/science.aau4732

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Effects of microbiota-directed foods in gnotobiotic animals and undernourished children

Journal article

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Effects of microbiota-directed foods in gnotobiotic animals and undernourished children

Jeanette Gehrig, Siddarth Venkatesh, Hao-Wei Chang, Matthew Hibberd, Vanderlene Kung, Jiye Cheng, Robert Chen, Sathish Subramanian, Carrie Cowardin, Martin Meier, …

Science (American Association for the Advancement of Science), Vol.365(6449), p.139

12/07/2019

DOI: https://doi.org/10.1126/science.aau4732

PMCID: PMC6683325

PMID: 31296738

Abstract

Life Sciences

To examine the contributions of impaired gut microbial community development to childhood undernutrition, we combined metabolomic and proteomic analyses of plasma samples with metagenomic analyses of fecal samples to characterize the biological state of Bangladeshi children with severe acute malnutrition (SAM) as they transitioned, after standard treatment, to moderate acute malnutrition (MAM) with persistent microbiota immaturity. Host and microbial effects of microbiota-directed complementary food (MDCF) prototypes targeting weaning-phase bacterial taxa underrepresented in SAM and MAM microbiota were characterized in gnotobiotic mice and gnotobiotic piglets colonized with age- and growth-discriminatory bacteria. A randomized, double-blind controlled feeding study identified a lead MDCF that changes the abundances of targeted bacteria and increases plasma biomarkers and mediators of growth, bone formation, neurodevelopment, and immune function in children with MAM.

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Title: Effects of microbiota-directed foods in gnotobiotic animals and undernourished children
Creators - without role: Jeanette Gehrig - Washington University School of Medicine in St. Louis
Siddarth Venkatesh - Washington University School of Medicine in St. Louis
Hao-Wei Chang - Washington University School of Medicine in St. Louis
Matthew Hibberd - Washington University School of Medicine in St. Louis
Vanderlene Kung - Washington University School of Medicine in St. Louis
Jiye Cheng - Washington University School of Medicine in St. Louis
Robert Chen - Washington University School of Medicine in St. Louis
Sathish Subramanian - Washington University School of Medicine in St. Louis
Carrie Cowardin - Washington University School of Medicine in St. Louis
Martin Meier - Washington University School of Medicine in St. Louis
David O'Donnell - Washington University School of Medicine in St. Louis
Michael Talcott - Washington University School of Medicine in St. Louis
Larry Spears - Washington University School of Medicine in St. Louis
Clay Semenkovich - Washington University School of Medicine in St. Louis
Bernard Henrissat - Architecture et Fonction des Macromolécules Biologiques
Richard Giannone - Oak Ridge National Laboratory
Robert Hettich - Oak Ridge National Laboratory
Olga Ilkayeva - Duke Medical Center
Michael Muehlbauer - Duke University Medical Center
Christopher Newgard - Duke University Medical Center
Christopher Sawyer - Washington University School of Medicine in St. Louis
Richard Head - Washington University School of Medicine in St. Louis
Dmitry Rodionov - Department of Theoretical Physics and Astronomy [St Petersburg]
Aleksandr Arzamasov - Department of Theoretical Physics and Astronomy [St Petersburg]
Semen Leyn - Department of Theoretical Physics and Astronomy [St Petersburg]
Andrei Osterman - Sanford Burnham Prebys Medical Discovery Institute
Iqbal Hossain - International Centre for Diarrhoeal Disease Research
Munirul Islam - International Centre for Diarrhoeal Disease Research
Nuzhat Choudhury - International Centre for Diarrhoeal Disease Research
Shafiqul Sarker - International Centre for Diarrhoeal Disease Research
Sayeeda Huq - International Centre for Diarrhoeal Disease Research
Imteaz Mahmud - International Centre for Diarrhoeal Disease Research
Ishita Mostafa - International Centre for Diarrhoeal Disease Research
Mustafa Mahfuz - International Centre for Diarrhoeal Disease Research
Michael Barratt - Washington University School of Medicine in St. Louis
Tahmeed Ahmed - International Centre for Diarrhoeal Disease Research
Jeffrey Gordon - Washington University School of Medicine in St. Louis
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Publication Details: Science (American Association for the Advancement of Science), Vol.365(6449), p.139
Publisher: American Association for the Advancement of Science (AAAS)
Identifiers: 9936263108331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article