Abstract
Infection due to bacterial biofilm represents a serious health threat worldwide mostly due to the appearance of antibiotic resistant strains. Treatment of bacterial biofilm infection is currently a difficult and complicated challenge for microbiologists and clinicians. Antibiotics treatment alone is often inadequate to overcome bacterial biofilm infection so the necessity of research for alternative to inhibit biofilm formation. The purpose of this study was to investigate the efficacy of leaves extract of/Volvo parviflora as antibiofilm against different pathogens .The plant extraction was done with ethanol under cold extraction. Antibiofilm effect was evaluated for Staphylococcus aureus, Klebsiella pneumonia and Escherichia coli using 96 wells technique. The results revealed that leaves extract of Halm parviflora had efficacy to eradicate bioflm formed from most of isolates.