Abstract
Hematological effects are known to be the most frequent problems of malaria and play a significant role in malaria pathogenesis. The objective of this paper was to evaluate the hematological parameters and the coagulation profile of children less than five years of age with malaria. This is a case-control focused on 100 children under the age of five. Fifty children have been diagnosed with malaria as a case group. Additionally, 50 regular healthy children matched the gender and age group as the control group. PT and APTT were carried out using an automated coagulometer. CBC conducted with EDTA anticoagulant blood using an automated hematological analyzer. Based on the age of the patients, this study found that 56 percent of the cases were above three years of age. The present study stated that the male-to-female ratio was male: female 1:1.3. The current research found that hematological parameters were statistically and significantly lower in the patients' group compared to the normal control group with a P-value of less than 0.05, whereas the coagulation profile was significantly higher in the patients' group compared to the normal group (P-value less than 0.05). This study revealed that the hematological profile of children under five years of age with malaria also varies significantly from the control profile of coagulation increased in children with malaria.