Abstract
•This systematic review was based on the question, is aPDT effective in minimizing the growth of Candida on acrylic dentures?.•In this systematic review, eighteen in-vitro anti-microbial studies and 5 clinical studies were included.•Twenty-two studies suggested that aPDT was effective in reducing the Candida count on acrylic dentures.•19 out of 23 studies were graded as having ‘medium’ quality and 4 studies were graded as ‘high’ quality.•aPDT is effective in reducing Candida growth on acrylic dentures.
The aim of this systematic review was to critically analyze and summarize the currently available scientific evidence concerning antifungal efficacy of aPDT against Candida on acrylic surface.
The focused question was: ‘“Is aPDT effective in minimizing the counts of Candida on acrylic dentures”. A literature search was conducted interpedently on the following electronic research databases: PubMED/MEDLINE, Cochrane, Google Scholar and Embase. The MeSH terms used were: ((antimicrobial photodynamic therapy) OR (light) OR (laser) OR (photodynamic)) AND ((Candida) OR (denture stomatitis)) AND ((denture) OR (acrylic) OR (polymethylmethacrylate) OR (dental prosthesis)). Data was extracted from the studies and quality assessment was carried out using a modified version of the CONSORT checklist.
Eighteen in-vitro anti-microbial studies and 5 clinical studies were included. Twenty-two studies suggested that aPDT was effective in reducing the Candida count on acrylic dentures and one study did not have a significant effect. 19 out of 23 studies were graded as having ‘medium’ quality and 4 studies were graded as ‘high’. Several photosensitizers, including methylene blue, porphyrin derivatives, toluidine blue-O and others were used. LED was the most popular light source used for photo-activation of the photosensitizers.
Within the limitations of this review, aPDT is effective in reducing Candida growth on acrylic dentures and may prove to be clinical effective in preventing or treating denture stomatitis. However, more long-term clinical research is required before its clinical efficacy can be determined.