Abstract
OBJECTIVE: The aim was to assess the efficacy of subgingival minocycline hydrochloride (MH) delivery with non-surgical mechanical debridement (NSMD) for treating peri-implantitis in patients with type-2 diabetes mellitus (DM). PATIENTS AND METHODS: Type-2 diabet -ic and non-diabetic patients with peri-implanti-tis were included. In the test-group, patients un-derwent NSMD with a single session of MH de-livery. In the control-group, patients underwent NSMD alone. Hemoglobin A1c (HbA1c), modi-fied plaque-index (mPI), modified gingival in-dex (mGI), probing-depth (PD) and crestal bone loss (CBL) were measured at baseline and at 6-month follow-up. Level of significance was set at p<0.01. RESULTS: Thirty type-2 diabetic and 30 healthy individuals with peri-implantitis were included. There was a significant reduction in mPI (p<0.01), PD (p<0.01) and mGI (p<0.01) at 6 months among patients with and without type-2 DM in the test and control groups. There was no significant difference in peri-implant parameters in all patients at the 6-month follow-up. There was no significant difference in HbA1c and CBL among patients with and without type-2 DM in the test and control groups when baseline val-ues were compared with those at 6 months of follow-up. CONCLUSIONS: A single application of sub-gingival MH delivery is as effective as NSMD alone for the treatment of peri-implantitis in type-2 diabetic patients.