Abstract
Background
Anti-fibrinolytic medications decrease traumatic intracranial haemorrhage (ICH). Tranexamic acid (TXA) is an antifibrinolytic, which recently has shown effectiveness in management of traumatic haemorrhage.
Aims
To summarize the randomized control trials (RCTs) that evaluates the efficacy of tranexamic acid administration in traumatic brain injury (TBI) patients.
Methods
An electronic literature review, including PubMed, Google Scholar, and EBSCO that examining RCTs, observational, and experimental studies which study the efficacy of TXA administration in (TBI) patients.
Results
The current review included 7 randomized studies reported the efficacy of TXA in management of TBI. TXA limit secondary brain injury by preventing the expansion of ICH. Administration of TXA exhibited a tendency to decrease head trauma-related mortality.
Conclusion
TXA significantly lower the risk of ICU expansion m and prevent brain injury related deaths.