Abstract
A concise one-step procedure was developed for the synthesis of some newer tetrahydro-4H-benzo[1,3-e]oxazines and -acylamino ketone derivatives via condensation of cyclohexanone derivative with different aromatic aldehydes and nitriles in the presence of tetrachlorosilane/zinc chloride (TCS/ZnCl2) reagent mixture under ambient conditions. Docking studies for the synthesized benzo-oxazine derivatives were designed and a model of highly active derivatives was mapped for the antimicrobial screening.