Abstract
An efficient synthesis of the hitherto unknown ring system, 2-heteroaryl-thiazoles, is described via the reaction of 3-oxo-N-(4-phenylthiazol-2-yl)butanamide (1) with diazotized heterocyclic amine, phenyl isothiocyanate, dimethylformamide-dimethylacetal, and hydrazine hydrate, and the reaction of 2-chloro-N-(4-phenylthiazol-2-yl)acetamide (13) with some sulfur nucleophiles and malononitrile. The structures of the compounds prepared were determined by analytical and spectral analyses.