Abstract
A series of novel fused thiadiazine derivatives have been simply synthesized through the reaction of hydrazinecarbodithioic acid with various cyclic anhydrides, followed by condensation with oxalyl chloride or chloroacetic acid derivatives. The structures of the synthesized compounds were characterized by spectroscopic and analytical measurements. The reaction conditions were optimized in terms of yield and reaction time using different reagents and bases. In silico prediction of the physicochemical properties, ADME parameters, and drug likeness of all synthesized compounds showed that most of them could be considered as drug-like candidates with a high potential for bioactivity.