Abstract
Abstract
Selective syntheses of S-acyl glutathiones
are achieved in 79-98% yields using 1-acyl-1H-benzotriazoles in the presence of potassium
bicarbonate in aqueous methanol at 20 ˚C. N-Acylation of S-(P-nitrobenzoyl)
glutathione with 1-acyl-1H-benzotriazoles followed
by deprotection of the P-nitrobenzoyl
groups under mild conditions gave 63-78% yields
of N-acyl glutathiones. These methodologies
should be useful for the S-acylation and N-acylation of peptides
and glycopeptides.