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Efficient chemoenzymatic synthesis of sialyl Tn-antigens and derivatives
Journal article   Peer reviewed

Efficient chemoenzymatic synthesis of sialyl Tn-antigens and derivatives

Li Ding, Hai Yu, Kam Lau, Yanhong Li, Saddam Muthana, Junru Wang and Xi Chen
Chemical communications (Cambridge, England), Vol.47(30), pp.8691-8693
14/08/2011
DOI: https://doi.org/10.1039/c1cc12732b
PMID: 21725542

Abstract

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
An N-terminal and C-terminal truncated recombinant alpha 2-6-sialyl-transferase cloned from Photobacterium sp. JH-ISH-224, Psp2,6ST(15-501)-His(6), was shown to be an efficient catalyst for one-pot three-enzyme synthesis of sialyl Tn (STn) antigens and derivatives containing natural and non-natural sialic acid forms.

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