Abstract
Due to current technology enhancement, molecular databases have exponentially grown requesting faster efficient methods that can handle these amounts of huge data. Therefore, Multi‐processing CPUs technology can be used including physical and logical processors (Hyper Threading) to significantly increase the performance of computations. Accordingly, sequence comparison and pairwise alignment were both found contributing significantly in calculating the resemblance between sequences for constructing optimal alignments. This research used the Hash Table‐NGram‐Hirschberg (HT‐NGH) algorithm to represent this pairwise alignment utilizing hashing capabilities. The authors propose using parallel shared memory architecture via Hyper Threading to improve the performance of molecular dataset protein pairwise alignment. The proposed parallel hyper threading method targeted the transformation of the HT‐NGH on the datasets decomposition for sequence level efficient utilization within the processing units, that is, reducing idle processing unit situations. The authors combined hyper threading within the multicore architecture processing on shared memory utilization remarking performance of 24.8% average speed up to 34.4% as the highest boosting rate. The benefit of this work improvement is shown preserving acceptable accuracy, that is, reaching 2.08, 2.88, and 3.87 boost‐up as well as the efficiency of 1.04, 0.96, and 0.97, using 2, 3, and 4 cores, respectively, as attractive remarkable results.