Abstract
Seven isoxazole containing Schiff bases 1-7 have been synthesized by the reaction of 5-amino-3,4-dimethylisoxazole and the corresponding active aldehyde. The structures of synthesized compounds have been established using spectroscopic (H-1 and C-13 NMR, FT-IR and MS) and elemental analyses. These compounds have been assayed by the disk diffusion method for antibacterial activity against two Gram-positive and two Gram-negative bacteria from which the minimum inhibitory concentration have been determined. Their molecular properties have also been calculated computationally to corroborate the antibacterial activity. Experimental and computational results indicate that chloro derivative of isoxazole Schiff base 4 is a better antibacterial agent than Amoxicillin.