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Efficient synthesis of tertiary amine by direct N-alkylation of secondary amine with carboxylic acid using Ni (0) encat catalyst
Journal article   Peer reviewed

Efficient synthesis of tertiary amine by direct N-alkylation of secondary amine with carboxylic acid using Ni (0) encat catalyst

Syed Aziz Imam Quadri, Tonmoy C. Das, Shivaji Jadhav and Mazahar Farooqui
Synthetic communications, Vol.48(3), pp.267-277
01/02/2018

Abstract

Encapsulated Ni N-alkylation sodium borohydride tertiary amine
In this article, direct N-alkylation of secondary amines with carboxylic acid is described. Readily available diversified carboxylic acid has been explored on variant secondary amines using encapsulated Nickel as catalyst and inexpensive sodium borohydride as the hydride source. High yields, mild reaction conditions, tolerance to sensitive functional group and facile operational procedure are the significance of the present methodology.

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